MAGISNAT has developed the OMICS Machine model through the multiomic approach, offering a comprehensive understanding of how genes, metabolites, and proteins intertwine within major categories such as the immune system, oxidative stress, inflammation, longevity, deficiency states, increased demands, specific conditions, physical activity, brain health, and sleep. Our goal is to provide people with the knowledge needed to make informed decisions and optimize individual wellbeing.

The OMICS Machine model identifies how natural molecules can provide beneficial effects within the studied biochemical pathways by discovering how to rebalance homeostasis.

Plant Extracts

Anthocyanins (Prickly Pear Extract)

Anthocyanins are a class of water-soluble flavonoids widely found in fruits and vegetables. They are potent antioxidants that help combat oxidative stress reducing damage caused by free radicals to cells, and they are also known for their anti-inflammatory properties.
Oxidative Stress Pathway, Immunity and Inflammation Pathway, Cell Function Pathway
  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Histidine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C4, Complement C5, Complement C1q, Complement C1r, Complement C1s, Complement C2, Complement C6, Complement C7, Complement C8, Complement C9, Complement C3a, Complement C5a, Complement Factor B, Complement Factor D, Complement Factor H, Complement Factor I, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG)

Prickly Pear, Blueberries, Pomegranate, Red Grapes, Cocoa, Nuts

Beta-Sitosterol (Nettle Extract)

Beta-sitosterol is a bioactive compound found in nettle extract, a plant known for its health-promoting properties. This phytosterol has been extensively studied for its potential anti-inflammatory, antioxidant, and hypocholesterolemic properties. Specifically, beta-sitosterol could help reduce cholesterol levels in the blood, thus improving cardiovascular health. Additionally, it has been suggested to play a role in supporting the immune system.

Lipid Metabolism Pathway, Cell Function Pathway, Immunity and Inflammation Pathway

  • Genomic: FADS1, FTO, APOA2, APOA5, APOC3, LIPC, TFAP2B, PCSK9, LPL, UCP1, ELOVL2, CPT2, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, ADIPOQ, INSR, PPARG, GRCh38.p14, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), L-Carnitine Acetyl-L-carnitine, Propionyl-L-carnitine, Butyryl-L-carnitine, Isovaleryl-L-carnitine, Hexanoyl-L-carnitine, Octanoyl-L-carnitine, Decanoyl-L-carnitine, Dodecanoyl-L-carnitine, Palmitoyl-L-carnitine, Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glutamine, Glycine, Histidine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine, Glucose, Cortisol, Cortisone, Estradiol, Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Various oils such as Corn Oil, Wheat Germ Oil, Cottonseed Oil, Nuts (Pecans, Cashews), Avocado, Pumpkin Seeds, Sea Buckthorn

Vitexin (Passionflower Extract)

Flavonoids are a family of natural compounds found in the plant kingdom and widely utilized in dietary supplement industry. Specifically, they belong to a class of plant secondary metabolites with a polyphenolic structure. In the Passiflora plant, commonly known as passionflower, various types of flavonoids are present, including vitexin. Vitexin intervenes in various biochemical processes such as inflammation, immunity, and oxidative stress.

Immunity and Inflammation Pathway, Oxidative Stress Pathway, Cell Function Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Histidine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Various berries such as Strawberries, Citrus Fruits, Passionflower

Hesperidin (Citrus Fruit Extract)

Hesperidin is a potent antioxidant that helps neutralize free radicals in our bodies. It has demonstrated anti-inflammatory properties, capable of reducing the production of pro-inflammatory cytokines and inhibiting the activity of enzymes involved in the inflammatory response. It can improve endothelial function, reduce artery inflammation, and lower blood pressure. Additionally, hesperidin can lower bad cholesterol (LDL) and increase good cholesterol (HDL), helping to prevent heart disease.

Oxidative Stress Pathway, Immunity and Inflammation Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Citrus Fruits such as Oranges, Tangerines, Grapefruits, Lemons

Hydroxytyrosol (Olive Tree Extract)

Hydroxytyrosol is a polyphenol found in olive fruit and olive leaves. It possesses antioxidant, anti-inflammatory, and cardioprotective properties. Studies on animal and cellular models have indicated that hydroxytyrosol can reduce oxidative damage, lower blood pressure, and improve endothelial function.
Oxidative Stress Pathway, Immunity and Inflammation Pathway
  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Olive Oil, Olive Fruits, Olive Leaves

Oleuropein (Olive Tree Extract)

Oleuropein is another polyphenol found in olive fruit and olive leaves. Specifically, it has been found that oleuropein can protect the brain from oxidative stress and may have a preventive role. It is also known for its anti-inflammatory properties. Additionally, oleuropein also appears to have positive effects on blood sugar regulation and lipid metabolism.

Oxidative Stress Pathway, Immunity and Inflammation Pathway, Lipid Metabolism Pathway, Carbohydrate Metabolism Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, FADS1, FTO, APOA2, APOA5, APOC3, LIPC, TFAP2B, PCSK9, LPL, UCP1, ELOVL2, CPT2, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, ADIPOQ, INSR, PPARG, GRCh38.p14, ADIPOQ, LEP, LEPR, KCNJ11, AMY1A, UCP2, UCP3, PPARG, PYGM
  • Metabolomic: Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), L-Carnitine (levocarnitine), Acetyl-L-carnitine, Propionyl-L-carnitine, Butyryl-L-carnitine, Isovaleryl-L-carnitine, Hexanoyl-L-carnitine, Octanoyl-L-carnitine, Decanoyl-L-carnitine, Dodecanoyl-L-carnitine, Palmitoyl-L-carnitine, Citric acid (citrate), Isocitric acid (isocitrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Malic acid (malate), Oxaloacetic acid (oxaloacetate), Alanine, Aspartic acid, Serine
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB, α-Amylase (Ptyalin), Salivary Lipase

Olive Oil, Olive Fruits, Olive Leaves

Polydatin (Polygonum Cuspidatum Extract)

Polydatin is derived from the roots of Polygonum cuspidatum and is the glycosylated form of resveratrol, with higher bioavailability. It is a natural molecule known for its antioxidant and anti-inflammatory properties. Additionally, polydatin aids lipid metabolism and protects endothelial cells. Polydatin also helps to absorb Vitamin D.
Oxidative Stress Pathway, Immunity and Inflammation Pathway, Lipid Metabolism Pathway
  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, FADS1, FTO, APOA2, APOA5, APOC3, LIPC, TFAP2B, PCSK9, LPL, UCP1, ELOVL2, CPT2, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, ADIPOQ, INSR, PPARG, GRCh38.p14
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), L-Carnitine (levocarnitine), Acetyl-L-carnitine, Propionyl-L-carnitine, Butyryl-L-carnitine, Isovaleryl-L-carnitine, Hexanoyl-L-carnitine, Octanoyl-L-carnitine, Decanoyl-L-carnitine, Dodecanoyl-L-carnitine, Palmitoyl-L-carnitine
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB

Polygonum Cuspidatum, Grapes, Peanuts, Cocoa-containing Products

Proanthocyanidins (Pine Bark Extract)

Proanthocyanidins are polyphenolic compounds with a strong antioxidant action, useful for microcirculation and blood circulation. Widely distributed in nature, proanthocyanidins are useful in preventing cardiovascular diseases and have anti-inflammatory properties.

Oxidative Stress Pathway, Immunity and Inflammation Pathway, Cell Function Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Pine Bark, Grape Seeds, Red Wine, Citrus Fruits, Blueberries

Resveratrol (Polygonum Cuspidatum Extract)

Resveratrol is a polyphenol found in grapes, mulberries, and cocoa, which has shown to possess several health benefits. Its antioxidant action helps counteract oxidative stress caused by free radicals, thus protecting cells from damage and slowing down the aging process. Additionally, resveratrol has demonstrated anti-inflammatory properties, which can be useful in reducing inflammation associated with various conditions. Resveratrol also helps to absorb Vitamin D.
Oxidative Stress Pathway, Immunity and Inflammation Pathway
  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Roots of Polygonum Cuspidatum, Black Grape Skin, Grape Juice, Red Wine, Peanuts, Blueberries, Red Fruits, Cocoa

Silymarin (Milk Thistle Extract)

Silymarin is a flavonoid extracted from the seeds of milk thistle, also known as silybum marianum. Its antioxidant effect counteracts the damaging action of free radicals in the body, protecting cells from harm. Additionally, silymarin is known for its hepatoprotective effects and can help protect the liver from toxic substances. The anti-inflammatory effects of silymarin help reduce inflammation and promote overall wellbeing.

Oxidative Stress Pathway, Cell Function Pathway, Immunity and Inflammation Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Histidine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Fruits and leaves of Milk Thistle

Vitamins

Vitamin A

Vitamin A refers to fat-soluble compounds found as preformed vitamin A (retinol) in animal products and as provitamin A carotenoids in fruits and vegetables. The three active forms of vitamin A in the body are retinol, retinal, and retinoic acid. It is essential for proper functioning of the visual system, cell regeneration, and immune system support.
Vitamin A Pathway, Immunity and Inflammation Pathway, Oxidative Stress Pathway
  • Genomic: BCO1, SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Eggs, Carrots, Spinach, Red Peppers

Vitamin B1

Thiamine is a water-soluble vitamin, also known as vitamin B1. It is present in the human body as free thiamine and in various phosphorylated forms such as thiamine monophosphate (TMP), thiamine pyrophosphate (TPP), etc. Vitamin B1 is essential for cellular energy metabolism, proper functioning of the nervous system, and heart health.

Vitamin B Pathway, Oxidative Stress Pathway, Cell Signaling Pathway

  • Genomic: ALPL, CBS, MTHFR, FUT2, CUBN, MTRR, SOD2, AS3MT, CYP1A2, ADORA2A, VEGFA, GHRL, CNTF, VEGFC, AGT, HGF, ADIPOQ, NGF, TH, BDNF, ANGPT2, AGRP, HSD11B1, ACE2, BDKRN2, DRD2, ESR1, ESR2, CNR1, INSR, FLT4, LEPR, NR3C2, MC4R, NRP2, NTRK1
  • Metabolomic: Citric acid (citrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Cortisol, Cortisone, Estradiol, Estrone, Testosterone, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Progesterone, Androstenedione, Aldosterone, Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, also known as prostacyclin), Prostaglandin A2 (PGA2), Prostaglandin B2 (PGB2), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Legumes, Whole Grains, Nuts, Seeds

Vitamin B12

Vitamin B12 stands out from other vitamins because it includes a metallic ion, cobalt. Consequently, the name cobalamin is used to describe compounds that have vitamin B12 activity. The human body utilizes vitamin B12 in the forms of methylcobalamin and 5-deoxyadenosylcobalamin. This vitamin plays a crucial role in the production of red blood cells, the functioning of the nervous system, and the synthesis of DNA.

Vitamin B Pathway, Oxidative Stress Pathway, Immunity and Inflammation Pathway

  • Genomic: ALPL, CBS, MTHFR, FUT2, CUBN, MTRR, SOD2, AS3MT, CYP1A2, ADORA2A, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, C5orf52, ARMH4, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, LTB4R, LTA4H, TNF, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic:Citric acid (citrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Cereals, Soy-based Products, Red Meat, Chicken, Seafood

Vitamin B6

Vitamin B6 is a water-soluble vitamin that encompasses six common forms: pyridoxal, pyridoxine (also known as pyridoxol), pyridoxamine, and their phosphorylated versions. The phosphorylated ester derivative pyridoxal 5'-phosphate (PLP) serves as the bioactive form of the coenzyme, participating in many enzymatic reactions and supporting numerous metabolic processes. Vitamin B6 is essential for maintaining nervous system health, producing energy, and forming hemoglobin.

Vitamin B Pathway, Oxidative Stress Pathway, Immunity and Inflammation Pathway

  • Genomic: ALPL, CBS, MTHFR, FUT2, CUBN, MTRR, SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Citric acid (citrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Fish, Chicken, Potatoes, Bananas, Spinach, Sunflower Seeds

Vitamin B9

Folate, also referred to as vitamin B9 or folacin, is a water-soluble vitamin. Naturally occurring folates appear in various chemical forms and are present in foods as well as in their metabolically active forms within the human body. Vitamin B9 for cell growth, DNA synthesis, and the protection of neuronal cells.
Vitamin B Pathway, Nucleotide Metabolism, Oxidative Stress Pathway
  • Genomic: ALPL, CBS, MTHFR, FUT2, CUBN, MTRR, AMPD1, EPAS1, GABPB1, FOXC2, NCOA1, NCOA2, RAVER1, MCM6, TERT, RFC4, PTBP2, SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4
  • Metabolomic: Citric acid (citrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin)

Spinach, Asparagus, Lentils, Citrus Fruits

Vitamin C

Vitamin C, commonly called ascorbic acid, is a potent antioxidant essential for bolstering the immune system and shielding cells from damage caused by free radicals. On a molecular level, vitamin C participates in various enzymatic reactions, including the synthesis of collagen, a vital protein for the health of skin, bones, and blood vessels. Furthermore, it enhances the absorption of non-heme iron, which is crucial for the formation of red blood cells.

Oxidative Stress Pathway, Vitamin C Pathway, Immunity and Inflammation Pathway

  • Genomic: SLC23A1, SOD2, AS3MT, CYP1A2, ADORA2A, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, C5orf52, ARMH4, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, LTB4R, LTA4H, TNF, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Citric acid (citrate), Isocitric acid (isocitrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Malic acid (malate), Oxaloacetic acid (oxaloacetate), Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Citrus Fruits, Kiwi, Bell Peppers, Broccoli, Strawberries

Vitamin D

Vitamin D is a fat-soluble vitamin essential for managing calcium and phosphorus metabolism, as well as maintaining bone health and supporting immune function. Its molecular mechanism involves conversion into its active form, vitamin D3 or calcitriol, through skin exposure to sunlight or consumption of vitamin D-rich foods. The active form of vitamin D binds to receptors in the cells of the gastrointestinal tract and kidneys, enhancing the absorption of calcium and phosphorus.
Vitamin D Pathway, Calcium Pathway, Immunity and Inflammation Pathway
  • Genomic: GC, CYP2R1, VDR, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, C5orf52, ARMH4, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, LTB4R, LTA4H, TNF, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, COL1A1
  • Metabolomic: Vitamin D (Calciferol), Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Some mushrooms, Cereals, Plant-based Milk

Vitamin E

Vitamin E refers to a group of eight fat-soluble compounds with antioxidant properties, including four tocopherol isoforms and four tocotrienol isoforms. Among these, only α-tocopherol fulfills human vitamin E requirements and holds the most nutritional significance. As a powerful antioxidant, it inhibits the spread of free radicals in cell membranes and plasma lipoproteins. Additionally, α-tocopherol likely plays a role in boosting certain aspects of cell-mediated immunity.

Vitamin E Pathway, Immunity and Inflammation Pathway, Oxidative Stress Pathway

  • Genomic: SCARB1, CD36, CYP4F2, SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, Transferrin, Ceruloplasmin, Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Vegetable oils, Nuts, Seeds, Spinach

Minerals

Iron

Iron is a vital mineral that plays a key role in the production of red blood cells and the delivery of oxygen to body tissues. On a molecular level, iron is a crucial component of hemoglobin, the protein in red blood cells that binds to oxygen in the lungs and carries it to every cell in the body. Additionally, iron is important for cellular energy production, the structure of numerous essential molecules, and the functioning of the immune system. Vitamin C enhances the absorption of iron.
Iron Pathway, Immunity and Inflammation Pathway, Cell Function Pathway
  • Genomic: SLC17A1, HFE, TMPRSS6, BTBD9, TFR2, TF, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, C5orf52, ARMH4, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, LTB4R, LTA4H, TNF, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, GABPB11, NCOA2, EPAS1, FOXC2, NCOA1, RAVER1, MCM6, TERT, PTBP2, RFC4
  • Metabolomic: Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glycine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG)

Red Meat, Spinach, Lentils, Nuts, Seeds

Selenium

Selenium is a crucial mineral that acts as an antioxidant and supports the immune system. On a molecular level, selenium is an essential part of several selenoproteins, which serve as antioxidants and participate in various biological processes, including immune system regulation and the production of thyroid hormones.

Selenium Pathway, Oxidative Stress Pathway, Cell Function Pathway, Immunity and Inflammation Pathway
  • Genomic: SELENOP, SELENOF, SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Leucine/Isoleucine, Lysine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG)

Brazil Nuts, Whole Grains, Brown Rice, Red Meat, Seafood

Other Substances

Acetyl-Carnitine

Acetyl-carnitine is formed by the esterification of an L-carnitine molecule with an acetyl group. This molecule is highly regarded for its antioxidant benefits and its excellent tolerability. Acetyl-carnitine aids in the transport of fatty acids into cells, thereby supporting energy production.

Lipid Metabolism Pathway, Cell Function Pathway, Immunity and Inflammation Pathway

  • Genomic: FADS1, FTO, APOA2, APOA5, APOC3, LIPC, TFAP2B, PCSK9, LPL, UCP1, ELOVL2, CPT2, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, ADIPOQ, INSR, PPARG, GRCh38.p14, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5
  • Metabolomic: Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), L-Carnitine Acetyl-L-carnitine, Propionyl-L-carnitine, Butyryl-L-carnitine, Isovaleryl-L-carnitine, Hexanoyl-L-carnitine, Octanoyl-L-carnitine, Decanoyl-L-carnitine, Dodecanoyl-L-carnitine, Palmitoyl-L-carnitine, Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Arginine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glutamine, Glycine, Histidine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine, Glucose, Cortisol, Cortisone, Estradiol, Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG), Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)

Avocado, soy

Scientific Article Box

  • Traina G. The neurobiology of acetyl-L-carnitine. Front Biosci (Landmark Ed). 2016 Jun 1;21(7):1314-29. doi: 10.2741/4459. PMID: 27100509.

Digestive Enzymes

Digestive enzymes such as amylase, protease, glucoamylase, lipase, cellulase, lactase, pectinase, and bromelain are essential for improving the digestion process. Amylase is an enzyme that plays a key role in digesting starches into simple sugars, such as glucose, which can be absorbed and utilized by the body for energy. Lipase is an enzyme involved in the digestion of fats by helping to break down triglycerides in food into fatty acids and glycerol. Bromelain is a proteolytic enzyme extracted from pineapple (Ananas comosus) and may help combat pain and swelling associated with inflammation. Lactase is an enzyme responsible for digesting lactose, the sugar found in milk and dairy products. The main function of proteases is to break down proteins into amino acids. Glucoamylase is an enzyme that aids in the digestion of carbohydrates. Cellulase is an enzyme responsible for digesting cellulose, which is degraded into cellobiose, a disaccharide formed by two glucose molecules. Pectinase, along with cellulase and hemicellulase, is an enzyme that aids in the digestion of plant-based foods, increasing their nutritional and prebiotic value.

Lipid Metabolism Pathway, Carbohydrate Metabolism Pathway, Amino Acids Metabolism Pathway, Immunity and Inflammation Pathway

  • Genomic: FADS1, FTO, APOA2, APOA5, APOC3, LIPC, TFAP2B, PCSK9, LPL, UCP1, ELOVL2, CPT2, AKR1C1, AKR1C2, AKR1C3, SRD5A3, ATXN1, FOXP1, NR3C2, RORA, SMAD6, PTPRD, ADIPOQ, INSR, PPARG, GRCh38.p14,  ADIPOQ,  LEP,  LEPR, KCNJ11,  AMY1A, UCP2,  UCP3,  PPARG, PYGM,  SCN9A, CLTRN,  RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10,  NFKB2, SYK, ALOX5
  • Metabolomic: Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), L-Carnitine (levocarnitine), Acetyl-L-carnitine, Propionyl-L-carnitine, Butyryl-L-carnitine, Isovaleryl-L-carnitine, Hexanoyl-L-carnitine, Octanoyl-L-carnitine, Decanoyl-L-carnitine, Dodecanoyl-L-carnitine, Palmitoyl-L-carnitine, Citric acid (citrate), Isocitric acid (isocitrate), α-Ketoglutaric acid (α-ketoglutarate), Succinic acid (succinate), Fumaric acid (fumarate), Malic acid (malate), Oxaloacetic acid (oxaloacetate), Alanine, Aspartic acid, Glutamic acid, Glutamine, Glycine, Serine, Arginine, Asparagine, Cysteine, Histidine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Threonine, Tryptophan, Tyrosine, Valine, Cortisol, Cortisone, Estradiol, Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Albumin, ApoA, ApoB, α-Amylase (Ptyalin), Salivary Lipase, Cystatin C, Cystatin D, Lysozyme, Lactoperoxidase, Secretory Immunoglobulin A (sIgA), Lactoferrin, Transferrin, Ceruloplasmin, Haptoglobin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), C-Reactive Protein (CRP), Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Myeloperoxidase (MPO), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)
Plant enzymes in their natural state are found in all uncooked or untreated plant-based foods. Sprouted seeds are also a rich natural source of digestive enzymes.

Melatonin

Melatonin is a hormone naturally synthesized by the human body to regulate the sleep-wake cycle. Melatonin derived from plants can help manage sleep-wake rhythms, and may also provide antioxidant benefits, potential anti-inflammatory effects, and support for the immune system.

Immunity and Inflammation Pathway, Cell Function Pathway, Cell Signaling Pathway, Oxidative Stress Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7, TMPRSS2, CYP2D6, IRF5, IL1B, TERT, PON1, LTA, TNFRSF1B, IL17A, IL6, C5orf52, ARMH4, LTB4R, LTA4H, TLR2, TLR4, HGF, EPHB4, IL1R1, IL4, IL6, IL10, NFKB2, SYK, ALOX5, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, SCN9A, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN, VEGFA, GHRL, CNTF, VEGFC, AGT, HGF, ADIPOQ, NGF, TH, BDNF, ANGPT2, AGRP, HSD11B1, ACE2, BDKRN2, DRD2, ESR1, ESR2, CNR1, INSR, FLT4, LEPR, NR3C2, MC4R, NRP2, NTRK1
  • Metabolomic: Arginine, Glutamine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Aspartic Acid, Cysteine, Glutamic Acid, Glycine, Leucine/Isoleucine, Lysine, Methionine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose, Estrone, Testosterone, Progesterone, Androstenedione, Aldosterone, Prostaglandin A2 (PGA2), Prostaglandin B2 (PGB2), Vitamin E
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG)

Whole grains, corn, oats, legumes such as lentils and beans, tomatoes, and radishes etc.

Scientific Article Box

  • Atayik MC, Çakatay U. Melatonin-related signaling pathways and their regulatory effects in aging organisms. Biogerontology. 2022 Oct;23(5):529-539. doi: 10.1007/s10522-022-09981-y. Epub 2022 Jul 27. PMID: 35895186.

N-acetylcysteine

N-acetylcysteine may play a role in protecting cells from oxidative damage, supporting lung function, and promoting liver health. N-acetylcysteine is involved in the production of glutathione, a potent antioxidant.

Oxidative Stress Pathway, Immunity and Inflammation Pathway, Cell Function Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1, TLR7 ,TMPRSS2 ,CYP2D6 ,IRF5 ,IL1B ,TERT ,PON1 ,LTA ,TNFRSF1B ,IL17A, C5orf52, ARMH4 ,LTB4R, LTA4H ,TLR2 ,TLR4 ,HGF ,EPHB4 ,IL1R1 ,IL4 , IL6 ,IL10, NFKB2 ,SYK ,ALOX5, GABPB1, NCOA2, NCOA1, FOXC2, EPAS1, RAVER1, MCM6, RFC4, TERT, PTBP2, VCAM1, TAS1R2, GRID1, GPRC5B, KCNJ11, FLG, ACTN3, MSTN
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S), Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4), Citrate, Isocitrate, α-Ketoglutarate, Succinate, Fumarate, Malate, Oxaloacetate, Alanine, Asparagine, Leucine/Isoleucine, Lysine, Phenylalanine, Proline, Serine, Threonine, Tyrosine, Valine, Glucose
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23), Albumin, ApoA, ApoB, Thyroxine-binding globulin (TBG), Corticosteroid-binding globulin (CBG)

N-acetyl-cysteine is a stable form of the amino acid L-cysteine. Cysteine is commonly found in high-protein foods such as chicken, eggs, and legumes.

Scientific Article Box

  • Raghu G, Berk M, Campochiaro PA, Jaeschke H, Marenzi G, Richeldi L, Wen FQ, Nicoletti F, Calverley PMA. The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress. Curr Neuropharmacol. 2021;19(8):1202-1224. doi: 10.2174/1570159X19666201230144109. PMID: 33380301; PMCID: PMC8719286.

Spermidine

Spermidine is a naturally occurring polyamine compound found in wheat germ and rice germ. The biochemical processes in which spermidine is involved include inflammation, immunity, and oxidative stress.

Oxidative Stress Pathway and Immunity and Inflammation Pathway

  • Genomic: SOD2, AS3MT, CYP1A2, ADORA2A, BPIFB4, SCN9A, CLTRN, RAVER1 ,TLR7 ,TMPRSS2 ,CYP2D6 ,IRF5 ,IL1B ,TERT ,PON1 ,LTA ,TNFRSF1B ,IL17A,C5orf52 ,ARMH4 ,LTB4R ,LTA4H ,TLR2 ,TLR4 ,HGF ,EPHB4 ,IL1R1 ,IL4 ,IL6 ,IL10, NFKB2 ,SYK ,ALOX5
  • Metabolomic: Aspartic acid, Cysteine, Glutamic acid, Glutamine, Glycine, Methionine, Vitamin E, Arginine, Histidine, Tryptophan, Cortisol, Cortisone, Estradiol, Dehydroepiandrosterone (DHEA), Dehydroepiandrosterone sulfate (DHEA-S),Prostaglandin E2 (PGE2), Prostaglandin D2 (PGD2), Prostaglandin F2α (PGF2α), Prostaglandin I2 (PGI2, prostacyclin), Thromboxane A2 (TXA2), Thromboxane B2 (TXB2), Leukotriene B4 (LTB4), Leukotriene C4 (LTC4), Leukotriene D4 (LTD4), Leukotriene E4 (LTE4)
  • Proteomic: Lactoperoxidase, Lactoferrin, Ceruloplasmin, Haptoglobin, Myeloperoxidase (MPO), Interleukin-6 (IL-6), Interleukin-8 (IL-8), C-Reactive Protein (CRP), S100A8/A9 (Calprotectin), Lysozyme, Secretory Immunoglobulin A (sIgA), Transferrin, Immunoglobulin A (IgA), Immunoglobulin G (IgG), Immunoglobulin E (IgE), Interleukin-1β (IL-1β), Transforming Growth Factor Beta (TGF-β), Matrix Metalloproteinases (MMP-8, MMP-9), Complement C3, Complement C5, Complement C3a, Complement C5a, Properdin, Interferon Gamma (IFN-γ), Interleukin-10 (IL-10), Interleukin-12 (IL-12), Interleukin-17 (IL-17), Interleukin-18 (IL-18), Interleukin-23 (IL-23)
Broccoli, cauliflower, tuber vegetables, mushrooms, nuts, cereals, and legumes.

Scientific Article Box

  • Ni YQ, Liu YS. New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases. Aging Dis. 2021 Dec 1;12(8):1948-1963. doi: 10.14336/AD.2021.0603. PMID: 34881079; PMCID: PMC8612618.
  • Bonetti G, Dhuli K, Michelini S, Michelini S, Michelini S, Ricci M, Cestari M, Bertelli M. Dietary supplements in lymphedema. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E200-E205. doi: 10.15167/2421-4248/jpmh2022.63.2S3.2761. PMID: 36479479; PMCID: PMC9710411.