Several genetic diseases feature conditions like fatigue and muscle weakness accompanied by pain. Examples are collagen synthesis defects and inherited or acquired ion channel and muscle protein myopathies. Muscle weakness can depend on muscle, nerve, brain, metabolic or mitochondrial defects. But a major trigger of muscle weakness and fatigue is exercise. The amount of exercise that triggers symptoms and the frequency of symptoms are highly variable. Our research is focused on the study of a genetic and metabolomic test aimed at identifying genetic/allelic patterns or biomarkers that can significantly alter the muscle phenotype with tendencies toward negative muscle trophic evolution. Thus, this study is aimed at identifying a relationship between genetics, physical activity, and caloric intake. So that a test can be developed that can guide to personalized training programs and specific diet and nutrition schedules. Natural molecules of the typical plants of the Mediterranean diet, including polyphenols from olive trees, due to their many beneficial properties, could play a very important role in this field.
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*“None of the reported studies or the patent can be used to claim the properties of dietary supplements. Dietary supplements do not possess any therapeutic or preventive properties.”